Objective Tests for Schizophrenia

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  *updated periodically


16 question test that screens people for schizophrenia (if they are at high risk)

hair test for schizo – hydrogen sulfide
https://www.medicalnewstoday.com/articles/326837.php#1 

Memory test. Possible in youth
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-12-64
Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
Mario Fioravanti, Valentina Bianchi & Maria Elena Cinti 
BMC Psychiatryvolume 12, Article number: 64 (2012) 

D-serine levels in carbrospinal fluid versus serine levels are off in schizophrenics

The sensitivity and specificity of agmatine plasma test for the diagnosis of schizophrenia were 83.3% and 93.8%
(See drive)
Agmatine levelðng=mLÞ¼55:2 þ ½0:835 -
 Age ðyearÞ
þ ð0:697 -
 PANSS scoreÞ
Can also measure severity of illness
Correlates with age too (interesting) and prostate cancer

Skin flush test (82% don't have in schiz versus 23% in controls)
Large statistical difference in patients vs. controls

Semantic vagueness plus word use 90% accurate
https://www.sciencedaily.com/releases/2019/06/190613104552.htm

ECG brain scan plus how accurately you can respond to stimulus light markings with and without masking. How fast and accurately you distinguish stimuli (response is sadly close with depression and seemingly identical with bipolar)
https://www.sciencedirect.com/science/article/abs/pii/S0925492718301720

another blood test? antioxidant enzyme is abnormal (higher)
https://pubmed.ncbi.nlm.nih.gov/32772768/

blood test (seems fairly accurate in young people only, High CRMP2 also causes dendrites to be smaller )
heart rate accuracy of self assessment or self percieved time passing, heart more predictive than time. for schizo taking antipsychotic
https://www.psychiatryadvisor.com/home/topics/schizophrenia-and-psychoses/hallucination-symptom-of-schizophrenia-associated-with-heart-rate-adjusted-interoceptive-accuracy/

facebook posts predict schizo and mood disorders - 76% accuracy
https://healthitanalytics.com/news/machine-learning-facebook-data-offer-insight-into-schizophrenia

85% accurate, epigenetics (methylation patterns in the genome), versus 32% in polygenic risk score (just looking at genome of AT CG's)

Ammonia in breath indicates mental illness, also other things in breath (pentane) (80% accurate)
https://dl.acm.org/doi/abs/10.1145/3326172.3326212 (see drive schiz breath tests folder)

Schizophrenics often have a unique odour that can be detected and clears up on disease remission.

HOD test is linked here (subjective schizophrenia test that can be self administered):



Participants were administered a structured interview
that we had designed in order to elicit
uninterrupted speech. Questions included queries
such as “What would someone have to do if they
wanted to smoke a cigarette/wash their hair/do their
laundry”, as well as “tell me the story of Cinderella/
Romeo and Juliet”. Responses to these types of
questions tend to follow standard script-like themes.
Questions also included more abstract themes such as
“What is free-will/what is democracy/why do some
people believe in God?” (A complete interview is
available from the authors (BE) upon request).
Participants generally spoke for a minute or two in
response to each question, and no response was less
than eight words.
http://www.schres-journal.com/article/S0920-9964(07)00117-X/abstract ) 
82% accuracy for cinder cause longer answers then laundry (80%
100% with 1 hour interview about future plans with 5% chance of error in nature article

Used 8 word moving window compared to question
Used syntax too (most important var.)
Stepwise regression was used with 3-5 variables

Get more baseline
Contact health group more positives
Try determiners
Early intervention program
Website
work towards implementation

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