Less Interesting Info

New Anti Phychotic (Intra-Cellular Therapies' ITI-007) (Alkermes' ALKS-3831 also new like olazapine but less weight gain)
https://en.wikipedia.org/wiki/Lumateperone

invega saves money
https://www.psychiatryadvisor.com/schizophrenia-and-psychoses/schizophrenia-cardiometabolic-comorbidities-paliperidone-palmitate-oral-atypical-antipsychotics/article/743316/

womb
http://www.futurity.org/schizophrenia-pregnancy-1614232/

79% genes in twins plus they are working on seeing if twins have different genes
https://www.medicalnewstoday.com/articles/319674.php

memory deficit poor brain mapping
https://www.sciencedaily.com/releases/2017/09/170904120423.htm

possible new way to stop herditory schizo
https://www.medicalnewstoday.com/articles/318530.php

schizo can hear better
http://www.independent.co.uk/news/uk/good-hearing-mental-health-problems-schizophrenia-biploar-disorder-a7905066.html

immune response stop (new treatment
https://www.theguardian.com/society/2017/nov/03/radical-new-approach-to-schizophrenia-treatment-begins-trial

high kynurenic acid o learning sleep rem
https://medicalxpress.com/news/2017-09-intriguing-link-cognition-schizophrenia.html

(June 19 2018 search)

MRI of baby brain could be used to lower schizophrenia risk in pregnancy
https://sanvada.com/2018/06/19/moms-immune-system-affect-fetal-brain/

slower more variable motor response in schizophrenia
https://www.psychiatryadvisor.com/schizophrenia-advisor/functional-mri-cognitive-control-response-inhibition-schizophrenia/article/757359/

To high methionine could lead to schiz in pregnancy (can move up)
https://www.medicalnewstoday.com/articles/319040.php

new possible adjunct (developing)
https://www.medicalnewstoday.com/articles/318530.php
https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/190717/new-approach-to-fight-schizophrenia-discovered.html

video game MRI voices lessening
https://www.techspot.com/news/73271-preliminary-study-shows-video-game-effective-therapy-schizophrenia.html

HIV injected street drugs and schiz = x6
http://www.mdmag.com/conference-coverage/croi-2018/patients-with-hiv-six-times-as-likely-to-have-shizophrenia

social phobia and schizophrenia
https://medicalxpress.com/news/2017-12-social-phobia-linked-autism-schizophrenia.html

younger MRI had more hallucinations older had more social withdrawal
http://www.iflscience.com/health-and-medicine/anatomical-features-linked-to-multiple-types-of-schizophrenia/

Creative people 90% more likely to have schizophrenia
http://www.iflscience.com/health-and-medicine/being-creative-increases-your-risk-of-schizophrenia-by-90-percent/

causes of death for schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/29395608

testosterone differences
https://www.psychiatryadvisor.com/schizophrenia-advisor/dhea-dhea-s-testosterone-levels-schizophrenia/article/744479/

brain training possibility (promising)
https://peartherapeutics.com/thrive/
http://www.pharmatimes.com/news/novartis,_pear_to_develop_digital_therapies_for_schizophrenia,_ms_1225260

OCT 28, 2018 SEARCH

important signaling protein called G-CSF (granulocyte-colony stimulating factor) may help motivation
https://www.psychologytoday.com/ca/blog/brain-and-behavior/201810/deficits-in-cognition

Immune systen reboot cures schiz
https://www.nytimes.com/2018/09/29/opinion/sunday/schizophrenia-psychiatric-disorders-immune-system.html

Whole body disorder, cytokines higher. Inflamation, stress
https://newatlas.com/schizophrenia-whole-body-disorder/54647/
https://www.sciencedaily.com/releases/2018/07/180711131151.htm

Work help and schiz
https://bigthink.com/ned-dymoke/can-you-recover-from-schizophrenia-a-norwegian-study-suggests-you-can

depression toxaploma infection
https://www.psychiatryadvisor.com/schizophrenia-advisor/toxoplasmosis-infection-schizophrenia/article/774191/

Immune cells macrophages and schizophrenia
https://www.smh.com.au/healthcare/schizophrenia-breakthrough-scientists-suspect-immune-cells-20180412-p4z986.html

children of schizophrenics have cognitive impairments
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2685325

Jan 11 2019

Choline prevents babies from getting it? (can move up)
https://geneticliteracyproject.org/2019/01/11/can-we-reduce-schizophrenia-risk-with-prenatal-supplements/

common medications reduce schizo hospital admission rates
https://www.medicalnewstoday.com/articles/324154.php

diagnose
https://medicalxpress.com/news/2018-09-brain-schizophrenia-extreme-version-common.html

placenta
https://www.newscientist.com/article/2170242-faulty-placenta-may-explain-why-some-people-get-schizophrenia/

antibiotic may help within first 5 years
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(18)30345-6/fulltext

June 1st 2019

Glutetheon by brocolli extract (like NAC)
https://www.medicalnewstoday.com/articles/325212.php

SEP-363856 Drug that also helps negative symptoms Coming Probably
https://www.mdmag.com/medical-news/sep363856-for-treatment-of-schizophrenia

Bad genes in schizo
https://www.sciencedaily.com/releases/2019/05/190503100829.htm

Transcrianial magnetic stimulation helps negative symptoms
https://www.dovepress.com/repetitive-transcranial-magnetic-stimulation-as-an-adjunctive-treatmen-peer-reviewed-fulltext-article-NDT

MRI test
https://www.pnas.org/content/116/11/5108

Jan 1st 2020

weight gain and 18 different antychotics. Cholesterol too
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30416-X/fulltext

estrogen patch helps women
https://www.medscape.com/viewarticle/916820

mice given antiphychotic in teens didn't develop schizo
https://www.technologynetworks.com/neuroscience/news/schizophrenia-onset-prevented-in-mouse-model-323758

50% less likely to receive mammograms
https://www.psychcongress.com/article/women-schizophrenia-half-likely-receive-mammograms

restores spacial memory in schizo mice - gene SETD1A
https://www.sciencealert.com/scientists-have-reversed-a-core-symptom-of-schizophrenia-in-mice

Pollution increases schizo – Nitrogen dioxide
https://www.medscape.com/viewarticle/921104

50% of people falsely diagnosed schizo. Voices and anxiety most common culprits not neceserrily schizo
https://www.sciencedaily.com/releases/2019/04/190422090842.htm

hair test for schizo – hydrogen sulfide
https://www.medicalnewstoday.com/articles/326837.php#1

t Gondi parasite from cats 50% greater risk of schizo (can move up)
https://www.sciencealert.com/mind-altering-cat-parasite-linked-to-schizophrenia-in-largest-study-yet
rTMS
https://www.medscape.com/viewarticle/918011

T gondi also increases dopamine production in the brain (can double levels if highly infected)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177840/

https://www.youtube.com/watch?v=e3hu1Tpp4AU

1 in 4 people are infected with t Gondi

You can get it from cats, and undercooked pork, lamb, goat, poultry (organic meat actually has higher risk)

Supplementing B12 and Folate (B9) prevents many of the cognitive deficits of T gondi

https://www.youtube.com/watch?v=71E7liHAJ2M

lots of hospital visits starting 5 years before first antyphotic given
https://www.psychiatryadvisor.com/home/schizophrenia-advisor/prediagnosis-healthcare-utilization-may-aid-earlier-schizophrenia-detection/

bacteria infection during pregnancy bad for men
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.18101206

wider mouth palate associated with mental deficit in schizo
https://www.psychiatryadvisor.com/home/schizophrenia-advisor/palate-width-as-developmental-marker-of-deficit-vs-nondeficit-schizophrenia/

higher brain glucose levels and insulin resistance
https://www.psychiatrictimes.com/schizophrenia/brain-glucose-insulin-resistance-and-memory-schizophrenia

poverty doubles schiz risk, childhood likeability is a factor too. (can move up)
https://www.concordia.ca/news/stories/2019/04/26/growing-up-in-poverty-doubles-diagnoses-of-psychosis-spectrum-illnesses-like-schizophrenia-research-says.html

new antiphychotics
http://www.pmlive.com/pharma_news/karunas_shares_spike_on_schizophrenia_drug_data_1317392
https://www.psychiatryadvisor.com/home/topics/schizophrenia-and-psychoses/novel-treatment-for-schizophrenia-gets-fdas-breakthrough-therapy-designation/

genes 18%
top 10 vs bottom 10% 4.6x different
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19080825

24% less chance if u had a dog when young (can move up)
https://www.sciencealert.com/people-diagnosed-with-schizophrenia-are-less-likely-to-have-owned-a-dog-growing-up

Those born blind dont get schiz (can move up)
https://futurism.com/neoscope/born-blind-dont-develop-schizophrenia

Less grey matter in thalimus hippocampus amygdala. With biggest risk schizo gene
https://www.eurekalert.org/pub_releases/2020-02/uosc-mns021220.php

March 18 2020

Singling protein missing in schizophrenia (new target)
https://www.nature.com/articles/s41467-019-14122-0

40% of schizo don't have reduced grey matter
https://www.sciencealert.com/brain-scans-reveal-a-second-type-of-schizophrenia-and-it-looks-surprisingly-normal

May 8

Lack of lipid that forms myelin sheaths in schizo sphingolipid S1P
www.medicalnewstoday.com/amp/articles/new-drug-target-for-schizophrenia

SEP 363856 drug shows promise, no side effects, hits the TAAR1 recepter. Not d2 recepter
https://www.google.com/amp/s/medicalxpress.com/news/2020-04-experimental-drug-schizophrenia.amp

Hidradenitis Suppurativa associated with 10x increase in schizo
https://www.psychiatryadvisor.com/home/topics/schizophrenia-and-psychoses/schizophrenia-markedly-more-prevalent-in-patients-with-hidradenitis-suppurativa/

Schizo have lower math scores than verbal scores
https://emilkirkegaard.dk/en/?p=8651

August 4 2020

synapse saving protein
https://www.sciencedaily.com/releases/2020/07/200717133234.htm

Methelynated DNA in schizo around SERT sertonin target. (not useful)
https://www.news-medical.net/news/20200709/DNA-hypermethylation-correlated-with-reduced-amygdala-volume-in-male-patients-with-schizophrenia.aspx

August 20

Stress 10% increase to schizophrenia from recent stressful life events (can move up)
Association of RecentStressfulLifeEventsWithMental andPhysicalHealthintheContextofGenomic andExposomicLiabilityforSchizophrenia

Nov 7

Smartphone can predict relapse
https://newatlas.com/health-wellbeing/machine-learning-schizophrenia-relapses-passive-smartphone-data/

Nov 25

Rate of hypothyroidism is higher
https://www.healio.com/news/endocrinology/20201109/rate-of-hypothyroidism-higher-in-adults-after-schizophrenia-diagnosis

T. Gondi reduces norepinephrine can cause overactive immune response (can move up)
https://www.sciencedaily.com/releases/2020/11/201116112914.htm

Dec 22

Gene pathway with an eye for predicting med effectiveness
https://medicalxpress.com/news/2020-12-gene-pathway-linked-schizophrenia-stem.html

Excersize lowers schiz risk in at risk mice
https://www.sciencedaily.com/releases/2020/12/201216094645.htm

Get rid of T. Gondii with crisper (can move up)
https://phys.org/news/2020-12-genetic-unwanted-side-effects-parasites.html

feb 26, 2021

Weinberger and his team demonstrated in 2018 roughly a third of the genes associated with schizophrenia were expressed by the placenta during complicated pregnancies
https://www.sciencealert.com/pregnancy-problems-and-placental-genes-further-reveal-chances-of-schizophrenia

And defective cilia in treatment resistant schizo
https://www.psychiatrictimes.com/view/defective-cilia-in-the-brain-linked-to-schizophrenia

Odd of relaspse variables
https://www.hcplive.com/view/study-schizophrenia-relapse-

Long acting plus cog remedition therapy in onset of schizo helps
https://www.cambridge.org/core/journals/psychological-medicine/article/abs/randomized-controlled-trial-of-cognitive-remediation-and-longacting-injectable-risperidone-after-a-first-episode-of-schizophrenia-improving-cognition-and-workschool-functioning/058F938C6890C446F4A42847AF59324Apredictors

Results showed associations between five baseline variables and real-life functioning at follow-up. These variables were neurocognition with everyday life and work skills, avolition with interpersonal relationships, positive symptoms with work skills and social cognition with work skills and interpersonal functioning.
https://www.healio.com/news/psychiatry/20210210/study-finds-uncommonly-assessed-variables-linked-to-schizophrenia-functional-outcomes

Marriage duration effects schizophrenia in children
https://www.medscape.com/viewarticle/912643#:~:text=They%20found%20that%20offspring%20born,parents%20married%204%20or%20more

High methionine effects phychosis
Google drive

High homocysteine caused by low folate in pregnancy leads to 2x risk of schizo in young adults (can move up)

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/1660588

June 1st, 2021

Fast home blood test for clozapine levels

https://theconversation.com/schizophrenia-new-blood-test-device-could-improve-treatment-160571

Cardiovascular autonomic neuropathy risk is 4x (61% schiz versus 15% general pop)

https://www.psychiatryadvisor.com/home/topics/schizophrenia-and-psychoses/testing-for-cardiovascular-autonomic-neuropathy-may-ease-detecting-early-stages-of-cvd/

The state of interconnected of the brain can effect drug responders from non-responders and shows in a fMRI

https://www.dovepress.com/temporal-dynamics-in-degree-centrality-of-brain-functional-connectome--peer-reviewed-fulltext-article-NDT

dementia risk very high in schizo

https://www.healio.com/news/psychiatry/20210315/older-adults-with-schizophrenia-may-have-increased-risk-for-dementia

Increase in teen girl suicide and mental health visits during covid-19 lockdown

https://www.theepochtimes.com/cdc-reports-51-percent-increase-in-suicide-attempts-among-teen-girls_3876131.html

Aug 23, 2021

mental health of homeless population (alcohol, drugs, schiz, depression)

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003750

Early onset schizo have brain differences in prefrontal cortex, hippacampus and cerbelum.

https://www.miragenews.com/patients-with-early-onset-schizophrenia-have-610998/

Sept 18. 2021

https://www.dovepress.com/the-impact-of-adverse-childhood-experiences-on-coping-strategies-in-sc-peer-reviewed-fulltext-article-PRBM

Nov 27, 2021

Gene for women

https://www.dovepress.com/association-of-two-variable-number-of-tandem-repeats-in-the-monoamine--peer-reviewed-fulltext-article-NDT

Loss of synaptic gain and loss of synaptic inhibition

https://www.medicalnewstoday.com/articles/schizophrenia-synaptic-dysfunction-plays-key-role#How-synaptic-dysfunction-links-to-symptoms

Jan 6, 2022

New target for drugs (mGlu1) helps negative symptoms, increases that neaurotransmitter

https://www.mentalhealthtoday.co.uk/news/mental-health-disorders/researchers-discover-promising-new-treatment-for-schizophrenia

Non-gene area of the genome or dark genome associated with schiz and bi polar

https://scitechdaily.com/recently-evolved-region-of-the-dark-genome-offers-clues-to-treatment-of-schizophrenia-and-bipolar-disorder/

Feb 1, 2022

Alcohol use disorder leads to 4x increase in violent behaviour in schiz, cocaine increases, cannabis does not (PayWalled)

https://journals.lww.com/psychopharmacology/Abstract/2021/11000/Lifetime_Cannabis_Use_Disorder_Is_Not_Associated.4.aspx

Brain Cell development is abnormal in schiz and majour depression ADHD autism, bipolar

https://www.technologynetworks.com/neuroscience/news/links-identified-between-brain-cell-development-and-schizophrenia-357613

Mar 18, 2022

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Apr 16, 2022

Inflammatory bowel disease 4x greater in schiz, 2x higher in those hospitalized more than once a year versus not

https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.16856

Oct 1, 2022

Leaky gut, altered microbiome linked to aggression in schiz (plant based diet can increase aggression)

https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-022-04255-w#citeas

t gondi effects processing ability in schiz 9%

https://www.sciencedirect.com/science/article/pii/S2215001322000348

schiz have greater hearing loss 4x

https://ps.psychiatryonline.org/doi/abs/10.1176/appi.ps.20220226

Anhedonia (lack of pleasure) connected to schizophrenia symptoms and functional ability

https://www.physiciansweekly.com/anhedonia-linked-to-negative-positive-symptoms-in-schizophrenia

Lack of pleasure study of effects of mental health conditions

https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2769239

Intermittent fasting helps Alzheimer's in mice and improves their blood brain barrier

https://www.lifespan.io/news/intermittent-fasting-protects-from-brain-injury-in-mice/?mc_cid=7cbd6da964&mc_eid=eb5ca8bfb7

Misfolded proteins in the brain of schizophrenics (apr 3, 2023)

https://www.kurzweilai.net/breakthrough-research-links-deformed-proteins-with-schizophrenia

Apr 29, 2023

schizophrenics more at-risk from high temperatures (bodies less well heat regulated due to antipsychotics)

https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2022GH000729

Anxiety, depression, distress, increase positive psychotic symptoms

https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-04531-3

Evenamide for treatment resistant schizophrenia (new potential drug) (works on voltage gated sodium channels (not dopamine))

https://www.labiotech.eu/trends-news/newron-striking-schizophrenia-study-results/

12 hour rythem of brain effected by schizophrenia

https://www.genengnews.com/neurological-disorders/schizophrenia/schizophrenia-patients-brains-demonstrate-abnormal-12-hour-cyclic-gene-activity/

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001688

Brain cell death after a psychosis (10x greater than normal) blood test for psychosis

https://elifesciences.org/articles/76391

Non-invasive brain stimulation helps (meta analysis) (paywalled)

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2793707

Largest single gene that leads to schizophrenia (40-fold increase in risk) effects mitochondria (chris palmer correct) (aug 18, 2023)

https://medicalxpress.com/news/2023-08-hypothesis-mitochondrial-dysregulation-contributor-schizophrenia.html

https://www.science.org/doi/10.1126/sciadv.adh0558

IBS mental disorders linked genetically

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-023-01212-4

Niacin skin flush response absence in schizophrenics and triglyceride levels are connected

https://doi.org/10.1016/j.plefa.2020.102084

https://doi.org/10.1016/j.plefa.2012.11.005

Also see objective tests blog post

Working on:

[paywalled] check out later (cured by homeopathy)

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1756381

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