Curing Tardive Dyskinesia (Akathisia, Parkinsonism, Acute Dystonia)

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Updated occasionally
Broken off from main article



Movement disorders

Tardive dyskinesia (32.3% of chronic institutionalized patients (focus on the ratio (as less than 32% will get it in the general schizophrenic population))
Most common
Irregular involuntary movements (face, eyes, mouth, sometime in the trunk, arms and legs)

Akathisia (31.3%)
Restlessness (hard to sit still)
Helped by beta blockers (50%+ improvement)
Vitamin B6 has been shown to help (50+% improvement in akathisia) at 600mg twice a day (1200mg total). (Please look up potential side effects and if this dose is to large for long term use or not.)
Increasing GABA (neurotransmitter) looks like a promising potential treatment to try (definitely worth trying/looking into)
Low iron may be implicated in akathisia (?)


Parkinsonism (23.2%)
Tremor (trembling) in hands, arms, legs, jaw, or head (generally not recommended to take anticholinergics)
Stiffness of the limbs and trunk
Slowness of movement
Impaired balance and coordination, sometimes leading to falls
Helped by increasing dopamine (even in most schizophrenics), L dopa helps
In three separate scientific studies, the ancient Chinese herb gou teng, also known as cat’s claw (Uncaria rhynchophylla), has been shown to improve the symptoms associated with Parkinson’s disease.
Manganese may help(?)
Lonliness has an association (25% increased risk)

Acute dystonia
Usually occurs within first few days of starting antipsychotics
Muscle movements in head, face and neck or abnormal postures
Helped by anticholinergics (but this is generally not recommended)
Can change medication

Curing Tardive dyskinesia (TD) stop coffee, DHEA?, exercise, ginkco biloba (at 240mg a day) causes a 50% reduction. anticholinergic bad. Can reduce drugs once over 50. (ginkco biloba may decrease the breakdown of antipsychotics in the liver, increasing your dose so use carefully) vit E at 1600mg in divided doses caused a 50% reduction in tardive too (dose levels started at 400mg and slowly increased) (I would try other tips before trying vitamin E (plus not as high a dose)) (see Google drive link) also taking magnesium and calcium might help (Google drive) a-Lipoic Acid may help targive at higher doses (30% improvement in rats)
Manganese (recommend)
-50% were 100% fixed, 8% with no improvement
-11mg manganese chelate a day is the upper limit generally -  the study used 15mg to 50mg manganese chelate in divided doses 3 times day (study from 1970 with first gen antipsychotics)
-Benefits appeared rapidly (within a few days usually)
-Tardive dyskinesia patients had 50% less manganese in their hair samples prior to supplementation
-Adding niacin to those who don’t or partially respond to just manganese often results in improvement
-One study had a bad reaction if taking haloperidol or antipsychotics from that family (phenothiazines, which includes chlorpromazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, and trifluoperazine) but this patient had many other disorders (including liver failure) and it is likely safe to take, especially if you pay attention to how you react
-Sexual dysfunction decreased in men and women (in the doctors general practice)
Yi Gan San – 87% average improvement (Japanese herbal mixture)
-81% improved, 18% stayed the same and 0% got worse – symptoms almost completely went away in responders
-Generally well tolerated
-2.5g powder 3 times a day before meals (7.5g total) or 1.5g extract 3 times a day duration 12 weeks
-25% improvement to positive symptoms, 45% improvement to negative and general symptoms
Branched chain amino acids (such as leucine) 40% reduction (truehope sells amino acids to help with antipsychotic withdrawal) (recommend)
Phosphatidylcholine (lecithin) helps somewhat (see drive)
Vesicular monoamine transporter 2 (VMAT 2) pharma treatment
52.3% reduction in AIMS test
Reduces amount of dopamine in the presynaptic cleft
Has many side effects (Tetrabenazine) much less side effects (Deutetrabenazine) (still 49% reported much improved or very much improved (but I think less effective than tetrabenzazine) 30% reported >50% improvement in symptoms  (AIMS test)
Other possibilities
Keto reduces seizures by 50% in epilepsy patients which may help Tardive Dyskinesia or parkinsonism??
Magnesium and calcium might help
DHEA might help
L dopa given to those withdrawn from antipsychotics caused TD to go down by increasing dopamine and causing dopamine receptors to become less sensitive as a result
You can try changing medication to one with less extrapyramidal side effects
anticholinergic also linked to cognitive impairment before 50 (effect size unknown) (it reduces another neurotransmitter, leaving you with to few)
Pregnenolone may help (see main schiz article)





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