Autism

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First published March 19, 2023
Updated Rarely



Diagnosis criteria changes
Nutrient deficiencies in soil (starting with mass agriculture
Total toxic load (of modern living) implicated with autism (diet, pharm, environment, play, outdoors, antibiotics, emf?)
Microbiome (apparently their was a study done that showed giving mothers/infants probiotics lead to a 100% reduction in autism (from 17% in control to 0% in those given probiotics (at age 13))) ("A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial" (2015) Partty)
"Mother's received 1x10^10 colony-forming units of Lactobacillus rhamnosus GG or placebo (microcrystalline cellulose) daily for 4 wk before expected delivery. After delivery, the capsule contents were given either to the children, or continuously to the mothers, if breast-feeding, for 6 months"
L. Rhamnosus GG also reduces allergies by 50% (in the child) if given to the mother 4 weeks before the due date and given to the baby for the first 6 months of life (A probiotic containing L. R. GG might be worth trying (especially if the mother has allergies) (probable recommend, but should research more) (I don't think there are negative side effects to this)
https://doi.org/10.1093/jn/137.3.794S (still need to check the linked studies here)
Vaginal seeding may help ceserian section babies (hypothesis) (recommended)
Older review study doubted if it would help
Vaginal births had reduced rates of autism
Vaccines (7.6X to 4.2X increased risk of autism depending on the study. Allergies, celiac diseae, ADHD, eczema, asthma, ear infections, fever, premature puberty, multiple sclerosis, more time in hospital, sleeping disorders, infant mortality, gastrointestinal disorder, crohns disease, ulcerative colitis, type 1 diabetes, neurodivergent disorder, learning disability, all significantly linked to vaccines).
https://doi.org/10.15761/JTS.1000186 (study done after the removal of thimerosal in 2001)
(Missing link to one more well done comparison study)
(See children's health defence for more info)
(Thimerosal (mercury) was nearly eliminated in vaccines for children 6 and under starting in 2001 (USA)) 
Unclear if no vaccines for the majority of people would lead to large health improvements or a small health decline. However, using vaccines for the most severe diseases only seems prudent. Do note: that many vaccinated diseases now also have a non-vaccine treatment pathway. Elimination of nearly all vaccines therefore might be the best approach for health conscious people.
Aiming for partially protective vaccines instead of completely protective vaccines might be a way to improve the harm benefit ratio (uncertain) (hypothesis).
Some hypothesize that it is the giving of multiple vaccines at once that messes up the immune system instead of staggering them one at a time.
Tetanus is a large issue for those who do dirty work, other vaccines may be important also (in the USA there was 30 tetanus cases and 3 to 6 tetanus deaths in 330 million people (perhaps 30 million americans did not get the tetanus shot/booster), in contrast in Afghanistan it caused 0.54% of all deaths (1,254 deaths) in 2020
Maybe the adjuvants in vaccines that increase the immune response act so strongly as to induce an immune response from molecules that should not have one. Hence the increased allergies and autism in vaccinated vs. unvaccinated children (and the better safety profile from live vaccines vs. dead ones).
Possible mitigation of vaccine immune overstimulation using spore based probiotic 
(See entry towards bottom of page)
Flu vaccine causes miscarriages, bell's palsy, inflammatory bowel disease. (Children's health defence data)
Adult women (also present to an extant in children) have over 2x greater immune response than men and therefore require only half the vaccine dose of a men to receive the same benefit. This would reduce vaccine side effects. (Women have ~80% of autoimmune illnesses (a greater immune response does reduce the severity of cancer, colds/flus, bacterial infections by half)). However, some specific vaccines have higher responses in men.
Live vaccines are safer than non-live vaccines in a large majority of use cases
Flu vaccine lowers risk of alzheimers in those over 65 (25% reduction in risk, polio vaccine 40% reduction, diphtheria or tetanus 59% reduction)
Another study had a 12% risk reduction of getting dementia after receiving 6 or more flu shots (over 65 (average age 75))
Strokes were >3x as likely during an hospitalization for an infection
Pneumonia (infection of the lungs) can lead to an increased risk of a heart attack (1.8x increased risk 5 years later (3.2x increased risk during infection) (see graph below))
https://doi.org/10.1056/NEJMra1808137 (see drive other folder pneumonia heart attack)



 Infant mortality vs. vaccination doses

Flu vaccine may not help?
Moderate to light exercise may help autoimmune conditions (if intense exercise causes discomfort)
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Swedish children's health exposures analysed from pregnancy to age 5 (followed up till age 21):
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Infection that required antibiotics 6 or more times versus never (2.28x increased risk of autism)
Smoking during pregnancy (2.92x increased risk of autism (more than 10 cigarettes a day)
Analgesic use (pain killer) during pregnancy (1.46x increased risk of autism)
Smoking in the home increased autism risk in a dose dependent manner (3.47x increased risk of autism; father smoked more than 15 cigarettes a day)
Stomach ache reported at 5 years old (2.3x increased risk of autism) (likely caused by mould)
Palmitoleic acid present in infant stool (2.0x less risk (breast milk))
Linolenic acid (seed oils ect) consumption in pregnancy had an association
Children without autism had more bacteria in their gut microbiome (some bacteria increased autism risk though) (Large effects, some bacteria up to 3.99x) (antibiotics, infant diet, mother smoking, breastfed, affected microbiome)
Difficult life event since birth (to age 5) (2.56x)
Paternal asthma diagnosis (1.71x increased risk of autism)
(Intellectual disability, ADHD, speach disorders, are also associated with some of the above factors (to a greater or lesser degree (see study))
Bacteria Rhamnosus GG didn't seem to be mentioned anywhere
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"The study surveyed 4,691 U.S. adults aged 18 and older, utilizing the Quick Environmental Exposure and Sensitivity Inventory (QEESI), a validated tool for assessing sensitivity to chemical exposures. Participants with very high chemical intolerance scores were compared to those with low scores and were asked to report the number of biological children they have who are diagnosed with ASD or ADHD by health professionals.

Parents in the highest decile of chemical intolerance scores were found to be 5.7 times more likely to have a child with autism compared to those in the lowest decile. Specifically, among parents classified as having high chemical intolerance, 24.2% reported a child with autism, compared to only 5.5% of parents in the low intolerance group. For ADHD, the risk was 2.1 times higher in the highest chemical intolerance group." Mercola (lookup study)
Low lithium levels in mothers leads to autism (?)
Children with autism have low lithium: James Greenblatt (I think this is now outdated? New evidence of lithium in drinking water below, though I have not done a literature search on the subject (and low lithium in children with autism may be a thing) (?).
Lithium in water causes autism (16.78x higher rates in the highest exposed group)
Antidepressants (SSRI) use in pregnancy led to 2.17x increase in autism, antidepressant use led to 1.87x increased risk (second or third trimester)
High glyphosate exposure (such as a farmer) leads to a 30% increase in autism in pregnancy (other pesticides/herbicides also implicated in the study).
Topiramate and valproate (anti-seizure) lead to 2 to 4x increase to intellectual disability and autism in pregnant mothers (there is anti-seizure medication that doesn't lead to autism)
Micro plastics in infancy
BPA levels (from plastics) in a mothers urine increased boys (but not girls) risk of developing autism (boys with low aromatase enzyme activity (and a BPA level in the top quartile) were 3.56x more likely to get autism. This accounted for 11.9% of autism in males with low aromatase enzyme activity (another study had 10.4% of all autism cases being caused by BPA)
Age at first birth
Propionic acid in shelf stable foods
Folic acid fortification in foods may increase autism (folate safer) (mercola)
Linoleic acid (from vegetable oils, pregnancy or young infant) linked to autism severity (see mercola other folder) (need to research more)
Television (lack of emotional response for child)
Environmental pollutants
EMF exposure (See drive other folder EMF mercola) (haven't fully read) 
Fewer siblings
Day care vs home?
Too much cleanliness
British children without bathrooms, hot water, and who had a shared kitchen were healthier (overall?) (without bathroom had the biggest effect singly, but having none cut risk of appendicectomy in half).
Other
BPA and phthalates (plastic consumption)
Percent still unknown
Those who use a dishwasher instead of hand washing more likely to get allergies as children and ezema
Glyphosate 
Autistic children aren't dying young thats why theres more of them.
Casein from cow milk in baby formula
Birth control pills increasing testosterone
Tylenol especially when in the womb or a baby or young leads to many if not most cases of autism

Supplementing selenium leads to a 40%(?) improvement in autism symptoms in a mice model of autism

Supplementing L-carnitine leads to a 18% improvement in humans with autism (5% placebo), 100mg per kg of childs weight in two divided doses (one evening, one morning).
https://doi.org/10.1016/j.rasd.2012.07.006 (also see drive other folder)
Another study had about a 20% improvement from 50mg of L-carnitine per kg of childs weight

Sulforaphane
"In a placebo-controlled, double-blind, randomized trial, young men (aged 13–27) with moderate to severe ASD received the phytochemical sulforaphane (n = 29)—derived from broccoli sprout extracts—or indistinguishable placebo (n = 15). The effects on behavior of daily oral doses of sulforaphane (50–150 μmol) for 18 wk"
Aberrant Behavior Checklist (34% improvement)
Social Responsiveness Scale (17% improvement)
Stopped working after discontinuation 

"The average Overall Benefit of diets was 2.36 (0 = no benefit, 4 = great benefit), which was substantially higher than for nutraceuticals (1.59/4.0) and psychiatric/seizure medications (1.39/4.0), p < 0.001. The average Overall Adverse Effects of diets was significantly lower than psychiatric/seizure medications (0.10 vs. 0.93, p < 0.001) and similar to nutraceuticals (0.16). Autism severity decreased slightly over time in participants who used diet vs. increasing slightly in those that did not (p < 0.001).
A "healthy diet" was most effective, a "gluten-free diet" had the least positive impact (out of the diets listed), when broken down into seperate areas of improvement the ketogenic diet seemed to do best. (see link below)

Twin study where autism was successfully reversed (completely in one child, partly in another)
Multimodality interventions starting at 20 months (after diagnosis with ASD)
Focus on clean diet, individualized nutrition, some supplements, toxin reduction, genetic analysis, speach therapy, cransacral therapy, homeopathy, etc..
Reevaluated at ~36 months
55% reduction in symptoms in one child (42 point reduction in the atec score) (still met DSM 5 criteria for autism after treatment)
91% reduction in symptoms in the other child (39 point reduction in atec score)

Omega 3's
Camels milk
Quercetin
Korean red ginseng
Licorice 

Stem cells unclear benefits (Apr 2024) (unrecommended (?))

Spore based probiotics can often cure food intolerances in autistic children (also helps with reducing an overstimulated immune system due to vaccination). The study also notes that in the vast majority of cases there aren't "good and bad bacteria", instead there are bacteria that are treated well and there are mistreated bacteria that are angry.
(See drive other folder spore)

Non-verbal autistic children can very often communicate using spelling boards or other less dexterous (than the tongue) means of communication (*sidenote: other animals can also often communicate "verbally" using assistance devices)

Autism costs the US economy 1.45% of total GDP (2015)




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